respiratory failure: The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. [NCIT:C26872]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
5266 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
952 |
6. Filter based on genotype QC (FinnGen only) |
917 |
Control definitions (FinnGen only)
Control conditions
not ILD_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
ILD-related respiratory insufficiency
based on the number of shared cases.
Similar with more cases:
- Interstitial lung disease
- Interstitial lung disease endpoints
- Other interstitial pulmonary diseases
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5976 | 2346 | 3557 |
| Only index persons | 4503 | 1795 | 2708 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.07 | 0.10 |
| Only index persons | 0.09 | 0.07 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 74.06 | 75.07 | 73.40 |
| Only index persons | 74.56 | 75.67 | 73.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 917 | 318 | 599 |
| Unadjusted period prevalence (%) | 0.24 | 0.12 | 0.30 |
| Median age at first event (years) | 72.21 | 69.97 | 73.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ILD_INSUFFICIENCY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_INSUFFICIENCY | 8.21 [6.16, 10.94] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.326 |
During the follow-up period (1.1.1998 — 31.12.2019), 1133 out of 1651 females with ILD_INSUFFICIENCY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_INSUFFICIENCY | 7.529 [5.54, 10.23] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 1687 out of 2465 males with ILD_INSUFFICIENCY died.
Mortality risk
Mortality risk for people of age
years, who have ILD_INSUFFICIENCY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.882% | 1.479% |
| 5 | 5.567% | 7.869% |
| 10 | 12.156% | 19.449% |
| 15 | 22.803% | 33.892% |
| 20 | 37.258% | 52.12% |
Relationships between endpoints
↥Index endpoint: ILD_INSUFFICIENCY – ILD-related respiratory insufficiency
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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