Interstitial lung disease endpoints

ILD_ENDPOINTS

interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

5266

6. Filter based on genotype QC (FinnGen only)

5097

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Interstitial lung disease endpoints based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 38350 16182 21649
Only index persons 27651 12043 15608
Unadjusted period prevalence (%)
Whole population 0.54 0.46 0.60
Only index persons 0.53 0.44 0.60
Median age at first event (years)
Whole population 71.02 71.12 70.96
Only index persons 70.42 69.93 70.79

-FinnGen-

Key figures

All Female Male
Number of individuals 5097 2006 3091
Unadjusted period prevalence (%) 1.25 0.79 1.55
Median age at first event (years) 69.24 66.61 70.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint ILD_ENDPOINTS and mortality.

Females

Parameter HR [95% CI] p-value
ILD_ENDPOINTS 3.129 [2.83, 3.46] < 0.001
Birth year 0.998 [0.99, 1.01] 0.654

During the follow-up period (1.1.1998 — 31.12.2019), 5154 out of 10663 females with ILD_ENDPOINTS died.

Males

Parameter HR [95% CI] p-value
ILD_ENDPOINTS 3.447 [3.02, 3.93] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 7550 out of 13773 males with ILD_ENDPOINTS died.

Mortality risk

Mortality risk for people of age

years, who have ILD_ENDPOINTS.

N-year risk Females Males
1 0.278% 0.578%
5 2.021% 3.367%
10 5.217% 8.484%
15 9.234% 15.625%
20 16.058% 25.4%

Relationships between endpoints

Index endpoint: ILD_ENDPOINTS – Interstitial lung disease endpoints

GWS hits: 11

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data