interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
5266 |
6. Filter based on genotype QC (FinnGen only) |
5097 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Similar endpoints
↥List of similar endpoints to Interstitial lung disease endpoints based on the number of shared cases.
Similar with more cases:
- Other interstitial pulmonary diseases
- Interstitial lung disease
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
- Diseases of the respiratory system
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 38350 | 16182 | 21649 |
Only index persons | 27651 | 12043 | 15608 |
Unadjusted period prevalence (%) | |||
Whole population | 0.54 | 0.46 | 0.60 |
Only index persons | 0.53 | 0.44 | 0.60 |
Median age at first event (years) | |||
Whole population | 71.02 | 71.12 | 70.96 |
Only index persons | 70.42 | 69.93 | 70.79 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 5097 | 2006 | 3091 |
Unadjusted period prevalence (%) | 1.25 | 0.79 | 1.55 |
Median age at first event (years) | 69.24 | 66.61 | 70.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ILD_ENDPOINTS and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
ILD_ENDPOINTS | 3.129 [2.83, 3.46] | < 0.001 |
Birth year | 0.998 [0.99, 1.01] | 0.654 |
During the follow-up period (1.1.1998 — 31.12.2019), 5154 out of 10663 females with ILD_ENDPOINTS died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
ILD_ENDPOINTS | 3.447 [3.02, 3.93] | < 0.001 |
Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 7550 out of 13773 males with ILD_ENDPOINTS died.
Mortality risk
Mortality risk for people of age
years, who have ILD_ENDPOINTS.N-year risk | Females | Males |
---|---|---|
1 | 0.278% | 0.578% |
5 | 2.021% | 3.367% |
10 | 5.217% | 8.484% |
15 | 9.234% | 15.625% |
20 | 16.058% | 25.4% |
Relationships between endpoints
↥Index endpoint: ILD_ENDPOINTS – Interstitial lung disease endpoints
GWS hits: 11