idiopathic pulmonary fibrosis: Idiopathic pulmonary fibrosis (IPF) is a nonneoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known cause.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2495 |
4. Check minimum number of eventsNone |
2495 |
5. Include endpointsNone |
2495 |
6. Filter based on genotype QC (FinnGen only) |
2401 |
Control definitions (FinnGen only)
Control exclude
ILD_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
J84
Name in latin
Morbus pulmonum interstitialis cum fibrosi
Similar endpoints
↥List of similar endpoints to
Idiopathic pulmonary fibrosis
based on the number of shared cases.
Similar with more cases:
- Other interstitial pulmonary diseases
- Interstitial lung disease
- Interstitial lung disease endpoints
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18549 | 7438 | 10834 |
| Only index persons | 13181 | 5367 | 7814 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.21 | 0.30 |
| Only index persons | 0.26 | 0.20 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 74.28 | 75.14 | 73.71 |
| Only index persons | 74.01 | 74.46 | 73.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2401 | 808 | 1593 |
| Unadjusted period prevalence (%) | 0.64 | 0.32 | 0.80 |
| Median age at first event (years) | 71.61 | 69.42 | 72.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint IPF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| IPF | 3.691 [3.29, 4.14] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 3391 out of 5474 females with IPF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| IPF | 3.607 [3.15, 4.13] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5042 out of 7688 males with IPF died.
Mortality risk
Mortality risk for people of age
years, who have IPF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.269% | 0.673% |
| 5 | 1.736% | 3.833% |
| 10 | 4.577% | 9.627% |
| 15 | 8.667% | 17.651% |
| 20 | 15.51% | 28.109% |
Relationships between endpoints
↥Index endpoint: IPF – Idiopathic pulmonary fibrosis
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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