interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
149 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
136 |
6. Filter based on genotype QC (FinnGen only) |
132 |
Control definitions (FinnGen only)
Control exclude
ILD_ENDPOINTS
Control conditions
not ILD_ELSEWHERE
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
ILD related to systemic autoimmune disease
based on the number of shared cases.
Similar with more cases:
- ILD and respiratory illness in diseases classified elsewhere
- Respiratory disorders in diseases classified elsewhere
- ILD, hospital admissions
- Interstitial lung disease
- Other interstitial pulmonary diseases
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 702 | 418 | 283 |
| Only index persons | 570 | 342 | 228 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.09 | 64.63 | 65.84 |
| Only index persons | 64.33 | 63.09 | 66.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 132 | 75 | 57 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 60.34 | 57.42 | 64.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ILD_SYST_AUTO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_SYST_AUTO | 3.699 [2.83, 4.84] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 320 females with ILD_SYST_AUTO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_SYST_AUTO | 3.464 [2.4, 5.01] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 205 males with ILD_SYST_AUTO died.
Mortality risk
Mortality risk for people of age
years, who have ILD_SYST_AUTO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.408% | 0.714% |
| 5 | 1.999% | 4.234% |
| 10 | 4.769% | 9.531% |
| 15 | 9.366% | 17.667% |
| 20 | 16.266% | 28.289% |
Relationships between endpoints
↥Index endpoint: ILD_SYST_AUTO – ILD related to systemic autoimmune disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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