lung disease: A disease involving the lung.
Respiratory disorders in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
RESP_ILL_DIS_CLASS_ELSEWHERE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
416 |
4. Check minimum number of eventsNone |
416 |
5. Include endpointsNone |
416 |
6. Filter based on genotype QC (FinnGen only) |
403 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Respiratory disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other diseases of pleura
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
- ILD differential diagnosis
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2217 | 1242 | 966 |
| Only index persons | 1831 | 1044 | 787 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.05 | 65.35 | 64.68 |
| Only index persons | 64.02 | 64.19 | 63.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 403 | 239 | 164 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.08 |
| Median age at first event (years) | 61.74 | 60.18 | 64.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint RESP_ILL_DIS_CLASS_ELSEWHERE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RESP_ILL_DIS_CLASS_ELSEWHERE | 3.745 [3.08, 4.55] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.194 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1005 females with RESP_ILL_DIS_CLASS_ELSEWHERE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RESP_ILL_DIS_CLASS_ELSEWHERE | 3.158 [2.5, 3.98] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 342 out of 764 males with RESP_ILL_DIS_CLASS_ELSEWHERE died.
Mortality risk
Mortality risk for people of age
years, who have RESP_ILL_DIS_CLASS_ELSEWHERE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.345% | 0.573% |
| 5 | 2.154% | 3.715% |
| 10 | 5.214% | 8.745% |
| 15 | 9.821% | 16.302% |
| 20 | 17.124% | 26.876% |
Relationships between endpoints
↥Index endpoint: RESP_ILL_DIS_CLASS_ELSEWHERE – Respiratory disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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