No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
20090 |
4. Check minimum number of eventsNone |
20090 |
5. Include endpoints |
20499 |
6. Filter based on genotype QC (FinnGen only) |
19780 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H53-H54
Name in latin
Perturbationes visus
Similar endpoints
↥List of similar endpoints to
Visual disturbances
based on the number of shared cases.
Similar with more cases:
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 163178 | 89574 | 72973 |
| Only index persons | 148634 | 83120 | 65514 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.32 | 2.57 | 2.04 |
| Only index persons | 2.81 | 3.06 | 2.50 |
| Median age at first event (years) | |||
| Whole population | 50.72 | 51.69 | 49.53 |
| Only index persons | 51.91 | 52.72 | 50.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19780 | 12095 | 7685 |
| Unadjusted period prevalence (%) | 4.40 | 4.75 | 3.86 |
| Median age at first event (years) | 57.73 | 55.42 | 61.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_VISUDISTURB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISUDISTURB | 1.19 [1.08, 1.31] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.113 |
During the follow-up period (1.1.1998 — 31.12.2019), 8393 out of 74214 females with H7_VISUDISTURB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISUDISTURB | 1.357 [1.23, 1.5] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 9442 out of 60739 males with H7_VISUDISTURB died.
Mortality risk
Mortality risk for people of age
years, who have H7_VISUDISTURB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.077% | 0.284% |
| 5 | 0.616% | 1.577% |
| 10 | 1.601% | 3.993% |
| 15 | 3.134% | 7.248% |
| 20 | 5.535% | 12.138% |
Relationships between endpoints
↥Index endpoint: H7_VISUDISTURB – Visual disturbances
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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