No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3228 |
4. Check minimum number of eventsNone |
3228 |
5. Include endpointsNone |
3228 |
6. Filter based on genotype QC (FinnGen only) |
3125 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified visual disturbances
based on the number of shared cases.
Similar with more cases:
- Visual disturbances
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20937 | 12748 | 8114 |
| Only index persons | 20164 | 12389 | 7775 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.31 | 0.37 | 0.23 |
| Only index persons | 0.39 | 0.46 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 57.71 | 58.25 | 57.03 |
| Only index persons | 58.13 | 58.64 | 57.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3125 | 2032 | 1093 |
| Unadjusted period prevalence (%) | 0.71 | 0.80 | 0.55 |
| Median age at first event (years) | 61.11 | 59.37 | 64.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_VISDISTNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISDISTNAS | 1.064 [0.91, 1.25] | 0.442 |
| Birth year | 0.996 [0.99, 1.01] | 0.456 |
During the follow-up period (1.1.1998 — 31.12.2019), 804 out of 9467 females with H7_VISDISTNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISDISTNAS | 1.189 [1.0, 1.42] | 0.056 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 663 out of 6009 males with H7_VISDISTNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_VISDISTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.212% |
| 5 | 0.623% | 1.269% |
| 10 | 1.643% | 3.219% |
| 15 | 3.098% | 6.222% |
| 20 | 5.677% | 10.411% |
Relationships between endpoints
↥Index endpoint: H7_VISDISTNAS – Other and unspecified visual disturbances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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