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Subjective visual disturbances

EFO MESH Endpoint Browser PheWeb

H7_VISUDISTURBSUB

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H53.1
  • Hospital discharge: ICD-9 — 3681A
  • Hospital discharge: ICD-8 — 37731
  • Cause of death: ICD-10 — H53.1
  • Cause of death: ICD-9 — 3681A
  • Cause of death: ICD-8 — 37731

2 out of 7 registries used, show all original rules.

9544

4. Check minimum number of events

None

9544

5. Include endpoints

None

9544

6. Filter based on genotype QC (FinnGen only)

9225

Control definitions (FinnGen only)

Control exclude H7_VISUALDISTBLIND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H53
Name in latin Perturbationes visus subjectivae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 60871 38080 22562
Only index persons 58721 37108 21613
Unadjusted period prevalence (%)
Whole population 0.92 1.09 0.63
Only index persons 1.17 1.36 0.83
Median age at first event (years)
Whole population 55.19 55.56 54.71
Only index persons 55.45 55.78 54.88

-FinnGen-

Key figures

All Female Male
Number of individuals 9225 6148 3077
Unadjusted period prevalence (%) 2.12 2.41 1.55
Median age at first event (years) 58.21 56.40 61.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_VISUDISTURBSUB and mortality.

Females

Parameter HR [95% CI] p-value
H7_VISUDISTURBSUB 0.958 [0.84, 1.09] 0.512
Birth year 0.996 [0.99, 1.0] 0.352

During the follow-up period (1.1.1998 — 31.12.2019), 2545 out of 31328 females with H7_VISUDISTURBSUB died.

Males

Parameter HR [95% CI] p-value
H7_VISUDISTURBSUB 0.98 [0.86, 1.12] 0.766
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 2080 out of 18475 males with H7_VISUDISTURBSUB died.

Mortality risk

Mortality risk for people of age

years, who have H7_VISUDISTURBSUB.

N-year risk Females Males
1 0.106% 0.145%
5 0.541% 0.977%
10 1.406% 2.615%
15 2.741% 5.366%
20 4.852% 9.15%

Relationships between endpoints

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Index endpoint: H7_VISUDISTURBSUB – Subjective visual disturbances

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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