No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4739 |
4. Check minimum number of eventsNone |
4739 |
5. Include endpointsNone |
4739 |
6. Filter based on genotype QC (FinnGen only) |
4568 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H53
Name in latin
Diplopia
Similar endpoints
↥List of similar endpoints to
Diplopia
based on the number of shared cases.
Similar with more cases:
- Visual disturbances
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 31915 | 16114 | 15679 |
| Only index persons | 29817 | 15235 | 14582 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.45 | 0.46 | 0.44 |
| Only index persons | 0.56 | 0.56 | 0.56 |
| Median age at first event (years) | |||
| Whole population | 58.10 | 57.83 | 58.33 |
| Only index persons | 57.67 | 57.47 | 57.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4568 | 2534 | 2034 |
| Unadjusted period prevalence (%) | 1.01 | 1.00 | 1.02 |
| Median age at first event (years) | 58.55 | 55.56 | 62.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_DIPLOPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DIPLOPIA | 1.261 [1.14, 1.39] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.297 |
During the follow-up period (1.1.1998 — 31.12.2019), 2368 out of 13939 females with H7_DIPLOPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DIPLOPIA | 1.231 [1.11, 1.36] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 2994 out of 13545 males with H7_DIPLOPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_DIPLOPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.156% | 0.261% |
| 5 | 0.883% | 1.563% |
| 10 | 2.033% | 3.62% |
| 15 | 3.659% | 6.976% |
| 20 | 6.374% | 11.805% |
Relationships between endpoints
↥Index endpoint: H7_DIPLOPIA – Diplopia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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