Visual field defects

H7_VISFIELDDEF

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H53.4
  • Hospital discharge: ICD-9 3684
  • Cause of death: ICD-10 H53.4
  • Cause of death: ICD-9 3684

2 out of 7 registries used, show all original rules.

2984

4. Check minimum number of events

None

2984

5. Include endpoints

None

2984

6. Filter based on genotype QC (FinnGen only)

2885

Control definitions (FinnGen only)

Control exclude H7_VISUALDISTBLIND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H53
Name in latin Defectus campi visualis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23456 11336 11957
Only index persons 21057 10440 10617
Unadjusted period prevalence (%)
Whole population 0.33 0.32 0.33
Only index persons 0.39 0.38 0.41
Median age at first event (years)
Whole population 61.46 60.49 62.29
Only index persons 60.42 59.50 61.34

-FinnGen-

Key figures

All Female Male
Number of individuals 2885 1468 1417
Unadjusted period prevalence (%) 0.64 0.58 0.71
Median age at first event (years) 60.98 56.97 65.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_VISFIELDDEF and mortality.

Females

Parameter HR [95% CI] p-value
H7_VISFIELDDEF 1.669 [1.52, 1.83] < 0.001
Birth year 0.994 [0.99, 1.0] 0.15

During the follow-up period (1.1.1998 — 31.12.2019), 2621 out of 10302 females with H7_VISFIELDDEF died.

Males

Parameter HR [95% CI] p-value
H7_VISFIELDDEF 1.77 [1.62, 1.94] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3731 out of 10733 males with H7_VISFIELDDEF died.

Mortality risk

Mortality risk for people of age

years, who have H7_VISFIELDDEF.

N-year risk Females Males
1 0.172% 0.307%
5 0.864% 1.93%
10 2.355% 4.547%
15 4.659% 8.466%
20 7.991% 14.145%

Relationships between endpoints

Index endpoint: H7_VISFIELDDEF – Visual field defects

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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