No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
5800 |
4. Check minimum number of eventsNone |
5800 |
5. Include endpoints |
9360 |
6. Filter based on genotype QC (FinnGen only) |
9012 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H49-H52
Name in latin
Alius strabismus
Similar endpoints
↥List of similar endpoints to
Other strabismus
based on the number of shared cases.
Similar with more cases:
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 120913 | 66402 | 54258 |
| Only index persons | 99190 | 55293 | 43897 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.73 | 1.90 | 1.52 |
| Only index persons | 1.87 | 2.03 | 1.68 |
| Median age at first event (years) | |||
| Whole population | 7.68 | 8.28 | 6.82 |
| Only index persons | 9.48 | 10.67 | 7.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9012 | 5867 | 3145 |
| Unadjusted period prevalence (%) | 2.05 | 2.30 | 1.58 |
| Median age at first event (years) | 23.15 | 21.07 | 27.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_STRABOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_STRABOTH | 1.246 [1.08, 1.43] | 0.002 |
| Birth year | 0.996 [0.99, 1.0] | 0.356 |
During the follow-up period (1.1.1998 — 31.12.2019), 1429 out of 37481 females with H7_STRABOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_STRABOTH | 1.379 [1.19, 1.6] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1586 out of 32399 males with H7_STRABOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_STRABOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.161% | 0.237% |
| 5 | 0.805% | 1.501% |
| 10 | 1.72% | 3.904% |
| 15 | 3.304% | 7.044% |
| 20 | 5.955% | 11.789% |
Relationships between endpoints
↥Index endpoint: H7_STRABOTH – Other strabismus
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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