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Vertical strabismus

DOID EFO Endpoint Browser PheWeb

H7_VERTISTRAB

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H50.2
  • Hospital discharge: ICD-9 — 3783
  • Hospital discharge: ICD-8 — 37302
  • Cause of death: ICD-10 — H50.2
  • Cause of death: ICD-9 — 3783
  • Cause of death: ICD-8 — 37302

2 out of 7 registries used, show all original rules.

1143

4. Check minimum number of events

None

1143

5. Include endpoints

None

1143

6. Filter based on genotype QC (FinnGen only)

1105

Control definitions (FinnGen only)

Control exclude H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H50
Name in latin Strabismus verticalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9645 5200 4422
Only index persons 8778 4806 3972
Unadjusted period prevalence (%)
Whole population 0.14 0.15 0.12
Only index persons 0.17 0.18 0.15
Median age at first event (years)
Whole population 28.68 28.55 28.72
Only index persons 30.56 30.52 30.61

-FinnGen-

Key figures

All Female Male
Number of individuals 1105 672 433
Unadjusted period prevalence (%) 0.25 0.26 0.22
Median age at first event (years) 46.71 43.37 51.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_VERTISTRAB and mortality.

Females

Parameter HR [95% CI] p-value
H7_VERTISTRAB 0.921 [0.77, 1.09] 0.349
Birth year 0.992 [0.98, 1.0] 0.078

During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 3370 females with H7_VERTISTRAB died.

Males

Parameter HR [95% CI] p-value
H7_VERTISTRAB 1.046 [0.89, 1.23] 0.586
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 2894 males with H7_VERTISTRAB died.

Mortality risk

Mortality risk for people of age

years, who have H7_VERTISTRAB.

N-year risk Females Males
1 0.086% 0.209%
5 0.507% 1.234%
10 1.248% 2.985%
15 2.428% 5.589%
20 4.468% 9.332%

Relationships between endpoints

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Index endpoint: H7_VERTISTRAB – Vertical strabismus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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