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Convergent concomitant strabismus

DOID EFO Endpoint Browser PheWeb

H7_CONVERSTRAB

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H50.0
  • Hospital discharge: ICD-9 — 3780
  • Hospital discharge: ICD-8 — 37300
  • Cause of death: ICD-10 — H50.0
  • Cause of death: ICD-9 — 3780
  • Cause of death: ICD-8 — 37300

2 out of 7 registries used, show all original rules.

2230

4. Check minimum number of events

None

2230

5. Include endpoints

None

2230

6. Filter based on genotype QC (FinnGen only)

2130

Control definitions (FinnGen only)

Control exclude H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H50
Name in latin Strabismus convergens concomitans

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 31953 16397 15488
Only index persons 27242 14182 13060
Unadjusted period prevalence (%)
Whole population 0.45 0.47 0.43
Only index persons 0.51 0.52 0.50
Median age at first event (years)
Whole population 6.21 6.47 5.83
Only index persons 6.67 7.01 6.31

-FinnGen-

Key figures

All Female Male
Number of individuals 2130 1356 774
Unadjusted period prevalence (%) 0.48 0.53 0.39
Median age at first event (years) 10.10 10.43 9.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_CONVERSTRAB and mortality.

Females

Parameter HR [95% CI] p-value
H7_CONVERSTRAB 1.266 [1.03, 1.56] 0.027
Birth year 0.993 [0.98, 1.0] 0.115

During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 8389 females with H7_CONVERSTRAB died.

Males

Parameter HR [95% CI] p-value
H7_CONVERSTRAB 1.261 [1.02, 1.56] 0.03
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 7962 males with H7_CONVERSTRAB died.

Mortality risk

Mortality risk for people of age

years, who have H7_CONVERSTRAB.

N-year risk Females Males
1 0.12% 0.25%
5 0.741% 1.622%
10 1.733% 3.733%
15 3.213% 7.03%
20 5.683% 11.43%

Relationships between endpoints

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Index endpoint: H7_CONVERSTRAB – Convergent concomitant strabismus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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