No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2174 |
4. Check minimum number of eventsNone |
2174 |
5. Include endpointsNone |
2174 |
6. Filter based on genotype QC (FinnGen only) |
2082 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Intermittent heterotropia
based on the number of shared cases.
Similar with more cases:
- Other strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 40828 | 21955 | 18837 |
| Only index persons | 29323 | 15895 | 13428 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.58 | 0.63 | 0.53 |
| Only index persons | 0.55 | 0.58 | 0.51 |
| Median age at first event (years) | |||
| Whole population | 5.28 | 5.40 | 5.07 |
| Only index persons | 6.80 | 7.08 | 6.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2082 | 1363 | 719 |
| Unadjusted period prevalence (%) | 0.48 | 0.54 | 0.36 |
| Median age at first event (years) | 23.59 | 21.56 | 27.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_INTERHETEROTRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_INTERHETEROTRO | 1.207 [0.97, 1.5] | 0.09 |
| Birth year | 0.999 [0.99, 1.01] | 0.839 |
During the follow-up period (1.1.1998 — 31.12.2019), 413 out of 17721 females with H7_INTERHETEROTRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_INTERHETEROTRO | 1.247 [1.01, 1.53] | 0.036 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 436 out of 15644 males with H7_INTERHETEROTRO died.
Mortality risk
Mortality risk for people of age
years, who have H7_INTERHETEROTRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.3% |
| 5 | 0.895% | 1.526% |
| 10 | 2.02% | 3.477% |
| 15 | 3.824% | 6.621% |
| 20 | 6.883% | 11.084% |
Relationships between endpoints
↥Index endpoint: H7_INTERHETEROTRO – Intermittent heterotropia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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