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Divergent concomitant strabismus

DOID EFO Endpoint Browser PheWeb

H7_DIVERGSTRAB

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H50.1
  • Hospital discharge: ICD-9 — 3781
  • Hospital discharge: ICD-8 — 37301
  • Cause of death: ICD-10 — H50.1
  • Cause of death: ICD-9 — 3781
  • Cause of death: ICD-8 — 37301

2 out of 7 registries used, show all original rules.

2927

4. Check minimum number of events

None

2927

5. Include endpoints

None

2927

6. Filter based on genotype QC (FinnGen only)

2827

Control definitions (FinnGen only)

Control exclude H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H50
Name in latin Strabismus divergens concomitans

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30557 17266 13194
Only index persons 27598 15794 11804
Unadjusted period prevalence (%)
Whole population 0.44 0.49 0.37
Only index persons 0.53 0.58 0.45
Median age at first event (years)
Whole population 13.93 14.80 12.62
Only index persons 13.95 14.85 12.74

-FinnGen-

Key figures

All Female Male
Number of individuals 2827 1828 999
Unadjusted period prevalence (%) 0.64 0.72 0.50
Median age at first event (years) 20.99 18.09 26.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_DIVERGSTRAB and mortality.

Females

Parameter HR [95% CI] p-value
H7_DIVERGSTRAB 1.402 [1.2, 1.63] < 0.001
Birth year 0.994 [0.99, 1.0] 0.189

During the follow-up period (1.1.1998 — 31.12.2019), 367 out of 5205 females with H7_DIVERGSTRAB died.

Males

Parameter HR [95% CI] p-value
H7_DIVERGSTRAB 1.47 [1.26, 1.71] < 0.001
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 424 out of 4879 males with H7_DIVERGSTRAB died.

Mortality risk

Mortality risk for people of age

years, who have H7_DIVERGSTRAB.

N-year risk Females Males
1 0.126% 0.247%
5 0.883% 1.752%
10 1.992% 4.215%
15 3.76% 8.247%
20 6.617% 14.032%

Relationships between endpoints

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Index endpoint: H7_DIVERGSTRAB – Divergent concomitant strabismus

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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