obsolete_refractive error: ['Deviations from the average or standard indices of refraction of the eye through its dioptric or refractive apparatus.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
10623 |
4. Check minimum number of eventsNone |
10623 |
5. Include endpoints |
11039 |
6. Filter based on genotype QC (FinnGen only) |
10503 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H49-H52
Name in latin
Perturbationes refractionis et accommodationis (oculi)
Similar endpoints
↥List of similar endpoints to
Disorders of refraction and accommodation
based on the number of shared cases.
Similar with more cases:
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 129024 | 71773 | 56859 |
| Only index persons | 107279 | 60800 | 46479 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.84 | 2.06 | 1.59 |
| Only index persons | 2.04 | 2.24 | 1.77 |
| Median age at first event (years) | |||
| Whole population | 16.51 | 19.23 | 12.93 |
| Only index persons | 25.00 | 29.26 | 19.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10503 | 6919 | 3584 |
| Unadjusted period prevalence (%) | 2.40 | 2.72 | 1.80 |
| Median age at first event (years) | 46.91 | 45.19 | 50.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_REFRAACCOMMODIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_REFRAACCOMMODIS | 1.15 [1.03, 1.29] | 0.016 |
| Birth year | 0.996 [0.99, 1.0] | 0.323 |
During the follow-up period (1.1.1998 — 31.12.2019), 2935 out of 56112 females with H7_REFRAACCOMMODIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_REFRAACCOMMODIS | 1.248 [1.09, 1.43] | 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2510 out of 44720 males with H7_REFRAACCOMMODIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_REFRAACCOMMODIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.227% |
| 5 | 0.712% | 1.458% |
| 10 | 1.848% | 3.313% |
| 15 | 3.315% | 6.2% |
| 20 | 5.755% | 10.422% |
Relationships between endpoints
↥Index endpoint: H7_REFRAACCOMMODIS – Disorders of refraction and accommodation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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