No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2029 |
4. Check minimum number of eventsNone |
2029 |
5. Include endpointsNone |
2029 |
6. Filter based on genotype QC (FinnGen only) |
1944 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H52
Name in latin
Presbyopia
Similar endpoints
↥List of similar endpoints to
Presbyopia
based on the number of shared cases.
Similar with more cases:
- Disorders of refraction and accommodation
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12798 | 7185 | 5554 |
| Only index persons | 11977 | 6753 | 5224 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.16 |
| Only index persons | 0.23 | 0.25 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 53.91 | 54.12 | 53.65 |
| Only index persons | 53.71 | 53.84 | 53.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1944 | 1236 | 708 |
| Unadjusted period prevalence (%) | 0.44 | 0.49 | 0.36 |
| Median age at first event (years) | 54.47 | 53.97 | 55.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PRESBYOPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PRESBYOPIA | 1.379 [1.18, 1.61] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.285 |
During the follow-up period (1.1.1998 — 31.12.2019), 328 out of 3648 females with H7_PRESBYOPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PRESBYOPIA | 1.398 [1.2, 1.63] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 432 out of 2916 males with H7_PRESBYOPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_PRESBYOPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.295% |
| 5 | 0.843% | 1.703% |
| 10 | 2.094% | 4.247% |
| 15 | 4.011% | 8.649% |
| 20 | 7.218% | 14.601% |
Relationships between endpoints
↥Index endpoint: H7_PRESBYOPIA – Presbyopia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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