obsolete_hyperopia:
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2454 |
4. Check minimum number of eventsNone |
2454 |
5. Include endpointsNone |
2454 |
6. Filter based on genotype QC (FinnGen only) |
2338 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H52
Name in latin
Hyperopia
Similar endpoints
↥List of similar endpoints to
Hypermetropia
based on the number of shared cases.
Similar with more cases:
- Disorders of refraction and accommodation
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 43985 | 23830 | 20105 |
| Only index persons | 33198 | 18331 | 14867 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.63 | 0.68 | 0.56 |
| Only index persons | 0.63 | 0.67 | 0.57 |
| Median age at first event (years) | |||
| Whole population | 7.22 | 7.69 | 6.59 |
| Only index persons | 9.13 | 10.16 | 7.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2338 | 1491 | 847 |
| Unadjusted period prevalence (%) | 0.53 | 0.59 | 0.43 |
| Median age at first event (years) | 50.00 | 48.75 | 52.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_HYPERMETRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_HYPERMETRO | 1.047 [0.92, 1.2] | 0.5 |
| Birth year | 0.994 [0.99, 1.0] | 0.16 |
During the follow-up period (1.1.1998 — 31.12.2019), 1035 out of 19706 females with H7_HYPERMETRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_HYPERMETRO | 1.28 [1.1, 1.49] | 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 874 out of 16671 males with H7_HYPERMETRO died.
Mortality risk
Mortality risk for people of age
years, who have H7_HYPERMETRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.108% | 0.214% |
| 5 | 0.595% | 1.629% |
| 10 | 1.473% | 3.821% |
| 15 | 2.768% | 7.326% |
| 20 | 4.922% | 12.191% |
Relationships between endpoints
↥Index endpoint: H7_HYPERMETRO – Hypermetropia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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