obsolete_myopia: ['A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4974 |
4. Check minimum number of eventsNone |
4974 |
5. Include endpointsNone |
4974 |
6. Filter based on genotype QC (FinnGen only) |
4732 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H52
Name in latin
Myopia
Similar endpoints
↥List of similar endpoints to
Myopia
based on the number of shared cases.
Similar with more cases:
- Disorders of refraction and accommodation
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 48541 | 28199 | 20125 |
| Only index persons | 43883 | 25892 | 17991 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.70 | 0.81 | 0.56 |
| Only index persons | 0.84 | 0.95 | 0.69 |
| Median age at first event (years) | |||
| Whole population | 26.98 | 31.34 | 20.76 |
| Only index persons | 28.57 | 32.28 | 23.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4732 | 3252 | 1480 |
| Unadjusted period prevalence (%) | 1.11 | 1.28 | 0.74 |
| Median age at first event (years) | 40.80 | 39.62 | 43.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_MYOPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MYOPIA | 1.275 [1.12, 1.45] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.238 |
During the follow-up period (1.1.1998 — 31.12.2019), 930 out of 21450 females with H7_MYOPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MYOPIA | 1.268 [1.08, 1.49] | 0.004 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 715 out of 15335 males with H7_MYOPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_MYOPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.216% |
| 5 | 0.567% | 1.516% |
| 10 | 1.732% | 3.595% |
| 15 | 3.437% | 6.607% |
| 20 | 6.059% | 11.048% |
Relationships between endpoints
↥Index endpoint: H7_MYOPIA – Myopia
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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