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Anisometropia and aniseikonia

DOID EFO Endpoint Browser PheWeb

H7_ANISOMETROPIA

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H52.3
  • Hospital discharge: ICD-9 — 3673
  • Hospital discharge: ICD-8 — 37002
  • Cause of death: ICD-10 — H52.3
  • Cause of death: ICD-9 — 3673
  • Cause of death: ICD-8 — 37002

2 out of 7 registries used, show all original rules.

1030

4. Check minimum number of events

None

1030

5. Include endpoints

None

1030

6. Filter based on genotype QC (FinnGen only)

1001

Control definitions (FinnGen only)

Control exclude H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H52
Name in latin Anisometropia sive aniseiconia

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13920 7671 6203
Only index persons 10627 5992 4635
Unadjusted period prevalence (%)
Whole population 0.20 0.22 0.17
Only index persons 0.20 0.22 0.18
Median age at first event (years)
Whole population 13.02 16.52 8.40
Only index persons 23.43 30.46 14.34

-FinnGen-

Key figures

All Female Male
Number of individuals 1001 650 351
Unadjusted period prevalence (%) 0.23 0.26 0.18
Median age at first event (years) 51.46 49.36 55.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_ANISOMETROPIA and mortality.

Females

Parameter HR [95% CI] p-value
H7_ANISOMETROPIA 0.844 [0.73, 0.97] 0.021
Birth year 0.992 [0.98, 1.0] 0.089

During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 5603 females with H7_ANISOMETROPIA died.

Males

Parameter HR [95% CI] p-value
H7_ANISOMETROPIA 1.023 [0.85, 1.22] 0.807
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 4430 males with H7_ANISOMETROPIA died.

Mortality risk

Mortality risk for people of age

years, who have H7_ANISOMETROPIA.

N-year risk Females Males
1 0.097% 0.203%
5 0.511% 1.122%
10 1.205% 2.815%
15 2.278% 5.208%
20 3.952% 8.999%

Relationships between endpoints

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Index endpoint: H7_ANISOMETROPIA – Anisometropia and aniseikonia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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