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Astigmatism

DOID EFO Endpoint Browser PheWeb

H7_ASTIGMATISM

obsolete_astigmatism: ['Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less diffuse area. This results from the radius of curvature in one plane being longer or shorter than the radius at right angles to it. (Dorland, 27th ed).']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H52.2
  • Hospital discharge: ICD-9 — 3672
  • Hospital discharge: ICD-8 — 37000
  • Cause of death: ICD-10 — H52.2
  • Cause of death: ICD-9 — 3672
  • Cause of death: ICD-8 — 37000

2 out of 7 registries used, show all original rules.

2154

4. Check minimum number of events

None

2154

5. Include endpoints

None

2154

6. Filter based on genotype QC (FinnGen only)

2003

Control definitions (FinnGen only)

Control exclude H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H52
Name in latin Astigmatismus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 32598 16827 15677
Only index persons 24791 12908 11883
Unadjusted period prevalence (%)
Whole population 0.46 0.48 0.44
Only index persons 0.46 0.47 0.45
Median age at first event (years)
Whole population 8.05 8.10 7.83
Only index persons 12.81 12.99 12.61

-FinnGen-

Key figures

All Female Male
Number of individuals 2003 1156 847
Unadjusted period prevalence (%) 0.44 0.45 0.43
Median age at first event (years) 44.62 39.95 51.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_ASTIGMATISM and mortality.

Females

Parameter HR [95% CI] p-value
H7_ASTIGMATISM 1.135 [0.97, 1.33] 0.117
Birth year 0.993 [0.99, 1.0] 0.126

During the follow-up period (1.1.1998 — 31.12.2019), 606 out of 13833 females with H7_ASTIGMATISM died.

Males

Parameter HR [95% CI] p-value
H7_ASTIGMATISM 1.082 [0.89, 1.31] 0.418
Birth year 0.991 [0.98, 1.0] 0.062

During the follow-up period (1.1.1998 — 31.12.2019), 571 out of 12724 males with H7_ASTIGMATISM died.

Mortality risk

Mortality risk for people of age

years, who have H7_ASTIGMATISM.

N-year risk Females Males
1 0.164% 0.179%
5 0.711% 1.335%
10 1.664% 3.468%
15 3.068% 6.704%
20 5.238% 11.303%

Relationships between endpoints

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Index endpoint: H7_ASTIGMATISM – Astigmatism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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