No definition available.
Other disorders of optic [2nd] nerve and visual pathways
DOID EFO Endpoint Browser PheWeb
H7_OPTNEUROTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2017 |
4. Check minimum number of eventsNone |
2017 |
5. Include endpoints |
2123 |
6. Filter based on genotype QC (FinnGen only) |
2038 |
Control definitions (FinnGen only)
Control exclude
H7_OPTNERVE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H46-H48
Name in latin
Aliae morbositates nervi optici et tractuum opticorum
Similar endpoints
↥List of similar endpoints to
Other disorders of optic [2nd] nerve and visual pathways
based on the number of shared cases.
Similar with more cases:
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18167 | 9612 | 8441 |
| Only index persons | 15970 | 8659 | 7311 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.26 | 0.28 | 0.24 |
| Only index persons | 0.30 | 0.32 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 49.41 | 48.19 | 50.72 |
| Only index persons | 48.82 | 47.35 | 50.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2038 | 1185 | 853 |
| Unadjusted period prevalence (%) | 0.45 | 0.47 | 0.43 |
| Median age at first event (years) | 53.09 | 48.88 | 58.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTNEUROTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNEUROTH | 1.58 [1.41, 1.77] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 1306 out of 7603 females with H7_OPTNEUROTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNEUROTH | 1.77 [1.58, 1.98] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 1541 out of 6538 males with H7_OPTNEUROTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTNEUROTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.134% | 0.413% |
| 5 | 0.666% | 2.349% |
| 10 | 1.952% | 5.49% |
| 15 | 3.891% | 10.277% |
| 20 | 6.709% | 16.732% |
Relationships between endpoints
↥Index endpoint: H7_OPTNEUROTH – Other disorders of optic [2nd] nerve and visual pathways
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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