No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
397 |
4. Check minimum number of eventsNone |
397 |
5. Include endpointsNone |
397 |
6. Filter based on genotype QC (FinnGen only) |
381 |
Control definitions (FinnGen only)
Control exclude
H7_OPTNERVE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H47
Name in latin
Aliae morbositates papillae/disci nervi optici non specificatae
Similar endpoints
↥List of similar endpoints to
Other disorders of optic disc
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3105 | 1814 | 1282 |
| Only index persons | 2939 | 1737 | 1202 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 41.97 | 39.97 | 44.82 |
| Only index persons | 42.63 | 40.60 | 45.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 381 | 240 | 141 |
| Unadjusted period prevalence (%) | 0.09 | 0.09 | 0.07 |
| Median age at first event (years) | 50.48 | 47.23 | 56.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTICDISCOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.21 [0.93, 1.57] | 0.153 |
| Birth year | 0.995 [0.99, 1.0] | 0.202 |
During the follow-up period (1.1.1998 — 31.12.2019), 102 out of 1503 females with H7_OPTICDISCOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.083 [0.84, 1.4] | 0.538 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 1051 males with H7_OPTICDISCOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTICDISCOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.177% |
| 5 | 0.814% | 1.259% |
| 10 | 1.812% | 3.309% |
| 15 | 3.528% | 5.975% |
| 20 | 6.072% | 9.793% |
Relationships between endpoints
↥Index endpoint: H7_OPTICDISCOTH – Other disorders of optic disc
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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