optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3181 |
4. Check minimum number of eventsNone |
3181 |
5. Include endpoints |
3473 |
6. Filter based on genotype QC (FinnGen only) |
3318 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of optic nerve and visual pathways
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27317 | 15860 | 11283 |
| Only index persons | 24341 | 14506 | 9835 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.45 | 0.32 |
| Only index persons | 0.47 | 0.53 | 0.38 |
| Median age at first event (years) | |||
| Whole population | 42.35 | 40.11 | 45.40 |
| Only index persons | 41.50 | 39.25 | 44.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3318 | 2182 | 1136 |
| Unadjusted period prevalence (%) | 0.76 | 0.86 | 0.57 |
| Median age at first event (years) | 44.93 | 40.34 | 53.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTNERVE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNERVE | 1.564 [1.39, 1.75] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 1571 out of 11910 females with H7_OPTNERVE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNERVE | 1.746 [1.56, 1.95] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1787 out of 8355 males with H7_OPTNERVE died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTNERVE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.338% |
| 5 | 0.888% | 2.093% |
| 10 | 2.284% | 4.916% |
| 15 | 4.457% | 9.159% |
| 20 | 7.639% | 15.306% |
Relationships between endpoints
↥Index endpoint: H7_OPTNERVE – Disorders of optic nerve and visual pathways
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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