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Disorders of optic nerve, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

H7_OPTNERVNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H47.0
  • Hospital discharge: ICD-9 — 3774
  • Hospital discharge: ICD-8 — 37799
  • Cause of death: ICD-10 — H47.0
  • Cause of death: ICD-9 — 3774
  • Cause of death: ICD-8 — 37799

2 out of 7 registries used, show all original rules.

635

4. Check minimum number of events

None

635

5. Include endpoints

None

635

6. Filter based on genotype QC (FinnGen only)

614

Control definitions (FinnGen only)

Control exclude H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H47
Name in latin Morbositates nervi optici non alibi classificatae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5048 2489 2516
Only index persons 4410 2212 2198
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 62.97 63.63 62.38
Only index persons 62.67 63.16 62.18

-FinnGen-

Key figures

All Female Male
Number of individuals 614 312 302
Unadjusted period prevalence (%) 0.14 0.12 0.15
Median age at first event (years) 62.19 59.66 64.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_OPTNERVNAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_OPTNERVNAS 1.359 [1.17, 1.58] < 0.001
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1941 females with H7_OPTNERVNAS died.

Males

Parameter HR [95% CI] p-value
H7_OPTNERVNAS 1.46 [1.26, 1.69] < 0.001
Birth year 0.989 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 567 out of 1962 males with H7_OPTNERVNAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_OPTNERVNAS.

N-year risk Females Males
1 0.108% 0.271%
5 0.801% 2.134%
10 2.05% 4.791%
15 3.769% 8.823%
20 6.255% 14.356%

Relationships between endpoints

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Index endpoint: H7_OPTNERVNAS – Disorders of optic nerve, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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