optic papillitis: Swelling of the optic disk, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause optic atrophy and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
723 |
4. Check minimum number of eventsNone |
723 |
5. Include endpointsNone |
723 |
6. Filter based on genotype QC (FinnGen only) |
695 |
Control definitions (FinnGen only)
Control exclude
H7_OPTNERVE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H47
Name in latin
Oedema papillae non specificatum
Similar endpoints
↥List of similar endpoints to
Papilloedema, unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5484 | 3197 | 2258 |
| Only index persons | 4991 | 2970 | 2021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.06 |
| Only index persons | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 42.25 | 38.70 | 47.19 |
| Only index persons | 41.63 | 37.90 | 47.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 695 | 435 | 260 |
| Unadjusted period prevalence (%) | 0.16 | 0.17 | 0.13 |
| Median age at first event (years) | 46.64 | 41.15 | 55.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PAPILLOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PAPILLOEDEMA | 1.805 [1.5, 2.18] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.933 |
During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 2534 females with H7_PAPILLOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PAPILLOEDEMA | 1.735 [1.45, 2.08] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1743 males with H7_PAPILLOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_PAPILLOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.222% | 0.329% |
| 5 | 1.191% | 2.395% |
| 10 | 2.856% | 5.595% |
| 15 | 5.566% | 10.492% |
| 20 | 10.02% | 17.3% |
Relationships between endpoints
↥Index endpoint: H7_PAPILLOEDEMA – Papilloedema, unspecified
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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