No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
567 |
4. Check minimum number of eventsNone |
567 |
5. Include endpointsNone |
567 |
6. Filter based on genotype QC (FinnGen only) |
538 |
Control definitions (FinnGen only)
Control exclude
H7_OPTNERVE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Optic atrophy
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5582 | 2664 | 2879 |
| Only index persons | 4719 | 2320 | 2399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 46.61 | 48.27 | 44.98 |
| Only index persons | 45.82 | 47.26 | 44.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 538 | 292 | 246 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.12 |
| Median age at first event (years) | 53.42 | 52.30 | 54.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTATROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTATROPHY | 1.873 [1.59, 2.2] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 468 out of 2068 females with H7_OPTATROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTATROPHY | 2.259 [1.92, 2.65] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 615 out of 2171 males with H7_OPTATROPHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTATROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.426% |
| 5 | 0.802% | 2.635% |
| 10 | 2.178% | 6.444% |
| 15 | 4.039% | 11.908% |
| 20 | 7.47% | 19.895% |
Relationships between endpoints
↥Index endpoint: H7_OPTATROPHY – Optic atrophy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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