chondrosarcoma: A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.
Benign neoplasm of bone and articular cartilage
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_BONE_CARTILAGE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2155 |
4. Check minimum number of eventsNone |
2155 |
5. Include endpoints |
3060 |
6. Filter based on genotype QC (FinnGen only) |
2965 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasma benignum ossis sive cartilaginis articularis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of bone and articular cartilage
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of bone and articular cartilage
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27315 | 13494 | 13693 |
| Only index persons | 25120 | 12600 | 12520 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.39 | 0.38 |
| Only index persons | 0.47 | 0.46 | 0.48 |
| Median age at first event (years) | |||
| Whole population | 31.98 | 37.34 | 26.57 |
| Only index persons | 30.96 | 36.54 | 25.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2965 | 1770 | 1195 |
| Unadjusted period prevalence (%) | 0.66 | 0.70 | 0.60 |
| Median age at first event (years) | 39.81 | 39.74 | 39.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_BONE_CARTILAGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_CARTILAGE | 1.057 [0.93, 1.21] | 0.407 |
| Birth year | 0.999 [0.99, 1.01] | 0.714 |
During the follow-up period (1.1.1998 — 31.12.2019), 530 out of 7903 females with CD2_BENIGN_BONE_CARTILAGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BONE_CARTILAGE | 1.056 [0.93, 1.2] | 0.408 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 589 out of 7613 males with CD2_BENIGN_BONE_CARTILAGE died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_BONE_CARTILAGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.165% |
| 5 | 0.603% | 1.185% |
| 10 | 1.661% | 2.905% |
| 15 | 3.341% | 5.841% |
| 20 | 6.078% | 9.778% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_BONE_CARTILAGE – Benign neoplasm of bone and articular cartilage
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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