No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
54128 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
13600 |
6. Filter based on genotype QC (FinnGen only) |
13159 |
Control definitions (FinnGen only)
Control conditions
not J10_ASTHMA
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Obesity related asthma
based on the number of shared cases.
Similar with more cases:
- Asthma
- Asthma
- Asthma, including avohilmo
- Chronic lower respiratory diseases
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 78409 | 40229 | 37839 |
| Only index persons | 74007 | 38403 | 35604 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.10 | 1.15 | 1.06 |
| Only index persons | 1.39 | 1.41 | 1.36 |
| Median age at first event (years) | |||
| Whole population | 53.29 | 54.12 | 52.40 |
| Only index persons | 53.16 | 53.99 | 52.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 13159 | 7645 | 5514 |
| Unadjusted period prevalence (%) | 2.90 | 3.00 | 2.77 |
| Median age at first event (years) | 54.29 | 53.62 | 55.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ASTHMA_OBESITY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_OBESITY | 1.786 [1.61, 1.98] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.127 |
During the follow-up period (1.1.1998 — 31.12.2019), 3456 out of 30650 females with ASTHMA_OBESITY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_OBESITY | 1.406 [1.28, 1.55] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 4136 out of 29048 males with ASTHMA_OBESITY died.
Mortality risk
Mortality risk for people of age
years, who have ASTHMA_OBESITY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.305% |
| 5 | 0.878% | 1.504% |
| 10 | 2.187% | 3.569% |
| 15 | 4.372% | 6.833% |
| 20 | 7.584% | 11.592% |
Relationships between endpoints
↥Index endpoint: ASTHMA_OBESITY – Obesity related asthma
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data