obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
27828 |
4. Check minimum number of eventsNone |
27828 |
5. Include endpoints |
28809 |
6. Filter based on genotype QC (FinnGen only) |
27711 |
Control definitions (FinnGen only)
Control exclude
E4_OBESITY_HYPER
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E65-E68
Name in latin
Obesitas
Obesity
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 207520 | 122748 | 83494 |
| Only index persons | 188132 | 112943 | 75189 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.03 | 3.52 | 2.33 |
| Only index persons | 3.64 | 4.15 | 2.87 |
| Median age at first event (years) | |||
| Whole population | 48.54 | 46.90 | 50.95 |
| Only index persons | 47.74 | 45.65 | 50.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 27711 | 18333 | 9378 |
| Unadjusted period prevalence (%) | 6.36 | 7.20 | 4.71 |
| Median age at first event (years) | 50.22 | 47.57 | 55.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_OBESITY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITY | 2.165 [1.95, 2.41] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.088 |
During the follow-up period (1.1.1998 — 31.12.2019), 8290 out of 89525 females with E4_OBESITY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITY | 2.128 [1.93, 2.35] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 9824 out of 62365 males with E4_OBESITY died.
Mortality risk
Mortality risk for people of age
years, who have E4_OBESITY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.361% |
| 5 | 1.077% | 2.149% |
| 10 | 2.722% | 5.613% |
| 15 | 5.357% | 10.93% |
| 20 | 9.317% | 18.155% |
Relationships between endpoints
↥Index endpoint: E4_OBESITY – Obesity
GWS hits: 55
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data