obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
20487 |
4. Check minimum number of eventsNone |
20487 |
5. Include endpointsNone |
20487 |
6. Filter based on genotype QC (FinnGen only) |
19661 |
Control definitions (FinnGen only)
Control exclude
E4_OBESITY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Obesity due to excess calories
based on the number of shared cases.
Similar with more cases:
- Obesity
- Obesity and other hyperalimentation
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 139360 | 80833 | 57952 |
| Only index persons | 132586 | 77999 | 54587 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.02 | 2.32 | 1.62 |
| Only index persons | 2.54 | 2.87 | 2.08 |
| Median age at first event (years) | |||
| Whole population | 48.19 | 45.78 | 51.66 |
| Only index persons | 48.20 | 45.67 | 51.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19661 | 12846 | 6815 |
| Unadjusted period prevalence (%) | 4.48 | 5.05 | 3.42 |
| Median age at first event (years) | 51.37 | 48.54 | 56.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_OBESITYCAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYCAL | 2.147 [1.93, 2.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.058 |
During the follow-up period (1.1.1998 — 31.12.2019), 6161 out of 66711 females with E4_OBESITYCAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYCAL | 2.061 [1.87, 2.28] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 7553 out of 48217 males with E4_OBESITYCAL died.
Mortality risk
Mortality risk for people of age
years, who have E4_OBESITYCAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.208% | 0.501% |
| 5 | 1.284% | 2.372% |
| 10 | 3.008% | 5.888% |
| 15 | 5.484% | 11.39% |
| 20 | 9.308% | 18.689% |
Relationships between endpoints
↥Index endpoint: E4_OBESITYCAL – Obesity due to excess calories
GWS hits: 27
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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