obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
300 |
4. Check minimum number of eventsNone |
300 |
5. Include endpointsNone |
300 |
6. Filter based on genotype QC (FinnGen only) |
288 |
Control definitions (FinnGen only)
Control exclude
E4_OBESITY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E66
Name in latin
Obesitas medicamento provocata
Similar endpoints
↥List of similar endpoints to
Drug-induced obesity
based on the number of shared cases.
Similar with more cases:
- Obesity
- Obesity and other hyperalimentation
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1947 | 1310 | 630 |
| Only index persons | 1879 | 1276 | 603 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 43.29 | 41.92 | 45.89 |
| Only index persons | 42.39 | 41.22 | 44.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 288 | 220 | 68 |
| Unadjusted period prevalence (%) | 0.07 | 0.09 | 0.03 |
| Median age at first event (years) | 47.20 | 44.53 | 55.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_OBESITYDRUG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYDRUG | 2.566 [2.01, 3.27] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.542 |
During the follow-up period (1.1.1998 — 31.12.2019), 125 out of 1189 females with E4_OBESITYDRUG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYDRUG | 3.083 [2.32, 4.1] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.065 |
During the follow-up period (1.1.1998 — 31.12.2019), 123 out of 581 males with E4_OBESITYDRUG died.
Mortality risk
Mortality risk for people of age
years, who have E4_OBESITYDRUG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.326% | 0.507% |
| 5 | 1.67% | 3.295% |
| 10 | 4.356% | 8.667% |
| 15 | 8.38% | 15.952% |
| 20 | 13.586% | 26.563% |
Relationships between endpoints
↥Index endpoint: E4_OBESITYDRUG – Drug-induced obesity
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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