obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1326 |
4. Check minimum number of eventsNone |
1326 |
5. Include endpointsNone |
1326 |
6. Filter based on genotype QC (FinnGen only) |
1289 |
Control definitions (FinnGen only)
Control exclude
E4_OBESITY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E66
Name in latin
Obesitas extrema cum hypoventilatione alveolari
Similar endpoints
↥List of similar endpoints to
Extreme obesity with alveolar hypoventilation
based on the number of shared cases.
Similar with more cases:
- Obesity
- Obesity and other hyperalimentation
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9083 | 4806 | 4240 |
| Only index persons | 8456 | 4518 | 3938 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.14 | 0.12 |
| Only index persons | 0.16 | 0.17 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 62.01 | 62.99 | 60.88 |
| Only index persons | 62.08 | 62.87 | 61.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1289 | 718 | 571 |
| Unadjusted period prevalence (%) | 0.28 | 0.28 | 0.29 |
| Median age at first event (years) | 58.97 | 57.49 | 60.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_OBESITYXTRMALV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYXTRMALV | 4.928 [4.15, 5.85] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.785 |
During the follow-up period (1.1.1998 — 31.12.2019), 1150 out of 3720 females with E4_OBESITYXTRMALV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYXTRMALV | 4.648 [3.91, 5.52] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1186 out of 3284 males with E4_OBESITYXTRMALV died.
Mortality risk
Mortality risk for people of age
years, who have E4_OBESITYXTRMALV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.708% | 0.697% |
| 5 | 3.189% | 4.419% |
| 10 | 7.568% | 11.367% |
| 15 | 13.934% | 20.929% |
| 20 | 25.508% | 33.412% |
Relationships between endpoints
↥Index endpoint: E4_OBESITYXTRMALV – Extreme obesity with alveolar hypoventilation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data