obesity: A disorder involving an excessive amount of body fat.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
14585 |
4. Check minimum number of eventsNone |
14585 |
5. Include endpointsNone |
14585 |
6. Filter based on genotype QC (FinnGen only) |
14035 |
Control definitions (FinnGen only)
Control exclude
E4_OBESITY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Obesity, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Obesity
- Obesity and other hyperalimentation
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 101521 | 63163 | 37539 |
| Only index persons | 87711 | 55646 | 32065 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.52 | 1.81 | 1.05 |
| Only index persons | 1.75 | 2.05 | 1.22 |
| Median age at first event (years) | |||
| Whole population | 48.13 | 47.17 | 49.69 |
| Only index persons | 46.49 | 45.16 | 48.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14035 | 9780 | 4255 |
| Unadjusted period prevalence (%) | 3.32 | 3.84 | 2.14 |
| Median age at first event (years) | 48.53 | 46.54 | 53.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_OBESITYNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYNAS | 2.219 [1.99, 2.48] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.862 |
During the follow-up period (1.1.1998 — 31.12.2019), 3644 out of 40743 females with E4_OBESITYNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OBESITYNAS | 2.399 [2.16, 2.66] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 4004 out of 24666 males with E4_OBESITYNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_OBESITYNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.497% |
| 5 | 1.528% | 2.936% |
| 10 | 3.373% | 7.02% |
| 15 | 6.864% | 13.363% |
| 20 | 11.998% | 22.102% |
Relationships between endpoints
↥Index endpoint: E4_OBESITYNAS – Obesity, other/unspecified
GWS hits: 19
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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