No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
54128 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
3206 |
6. Filter based on genotype QC (FinnGen only) |
3104 |
Control definitions (FinnGen only)
Control conditions
not J10_ASTHMA
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Suggestive for eosinophilic asthma
based on the number of shared cases.
Similar with more cases:
- Asthma
- Asthma
- Asthma, including avohilmo
- Chronic lower respiratory diseases
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 21151 | 9574 | 11468 |
| Only index persons | 19226 | 8895 | 10331 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.30 | 0.27 | 0.32 |
| Only index persons | 0.36 | 0.33 | 0.39 |
| Median age at first event (years) | |||
| Whole population | 51.33 | 50.38 | 52.09 |
| Only index persons | 50.40 | 49.51 | 51.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3104 | 1516 | 1588 |
| Unadjusted period prevalence (%) | 0.70 | 0.60 | 0.80 |
| Median age at first event (years) | 50.14 | 47.78 | 52.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ASTHMA_EOSINOPHIL_SUGG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_EOSINOPHIL_SUGG | 0.961 [0.87, 1.07] | 0.46 |
| Birth year | 0.995 [0.99, 1.0] | 0.228 |
During the follow-up period (1.1.1998 — 31.12.2019), 715 out of 6298 females with ASTHMA_EOSINOPHIL_SUGG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_EOSINOPHIL_SUGG | 0.787 [0.72, 0.86] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.077 |
During the follow-up period (1.1.1998 — 31.12.2019), 1120 out of 7644 males with ASTHMA_EOSINOPHIL_SUGG died.
Mortality risk
Mortality risk for people of age
years, who have ASTHMA_EOSINOPHIL_SUGG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.075% | 0.185% |
| 5 | 0.543% | 1.05% |
| 10 | 1.386% | 2.583% |
| 15 | 2.677% | 5.032% |
| 20 | 4.728% | 8.745% |
Relationships between endpoints
↥Index endpoint: ASTHMA_EOSINOPHIL_SUGG – Suggestive for eosinophilic asthma
GWS hits: 19
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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