eosinophilic pneumonia: An inflammatory lung disorder characterized by an increased number of eosinophils in the lungs. The majority of cases are idiopathic, without identifiable cause. In a minority of cases, medications, fungal infections, and environmental triggers have been implicated. It manifests as acute or chronic. Acute eosinophilic pneumonia is a severe and rapidly progressing pneumonia that may lead to respiratory failure requiring mechanical ventilation. Chronic eosinophilic pneumonia follows a slower course and manifests as fever, dyspnea, cough, and weight loss.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
393 |
4. Check minimum number of eventsNone |
393 |
5. Include endpointsNone |
393 |
6. Filter based on genotype QC (FinnGen only) |
378 |
Control definitions (FinnGen only)
Control exclude
J10_INTERSTITIUM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J80-J84
Name in latin
Eosinophilia pulmonum non alibi classificata
Similar endpoints
↥List of similar endpoints to
Pulmonary eosinophilia, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
- Other respiratory diseases principally affecting the interstitium
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3168 | 1780 | 1353 |
| Only index persons | 2462 | 1464 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.21 | 58.03 | 60.60 |
| Only index persons | 56.56 | 55.95 | 57.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 378 | 210 | 168 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | 57.77 | 54.02 | 62.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint J10_PULMEOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.613 [1.36, 1.91] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1053 females with J10_PULMEOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMEOS | 1.865 [1.56, 2.23] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 327 out of 857 males with J10_PULMEOS died.
Mortality risk
Mortality risk for people of age
years, who have J10_PULMEOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.372% |
| 5 | 0.928% | 2.274% |
| 10 | 2.312% | 5.463% |
| 15 | 4.365% | 9.521% |
| 20 | 7.696% | 15.863% |
Relationships between endpoints
↥Index endpoint: J10_PULMEOS – Pulmonary eosinophilia, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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