No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
G6_AD_WIDE, F5_DEMENTIA, F5_DEMENTIA_U, F5_PSYCH, NEURODIS, MEMLOSS, TRAUMBRAIN_NONCONCUS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Alzheimer’s disease (Early onset)
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease (Early onset)
- Alzheimer’s disease, wide definition
- Alzheimer’s disease, wide definition
- Any dementia
- Any dementia
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33683 | 20929 | 12434 |
| Only index persons | 27051 | 17263 | 9788 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.50 | 0.60 | 0.35 |
| Only index persons | 0.54 | 0.63 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 80.07 | 81.15 | 78.31 |
| Only index persons | 80.19 | 81.30 | 78.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1573 | 737 | 836 |
| Unadjusted period prevalence (%) | 0.36 | 0.29 | 0.42 |
| Median age at first event (years) | 76.28 | 74.37 | 77.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AD_EO_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_EO_EXMORE | 2.808 [2.51, 3.15] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 13192 out of 17872 females with AD_EO_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_EO_EXMORE | 3.402 [2.88, 4.02] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 7808 out of 10340 males with AD_EO_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have AD_EO_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.648% |
| 5 | 1.348% | 3.521% |
| 10 | 3.498% | 8.812% |
| 15 | 6.322% | 15.839% |
| 20 | 10.973% | 25.691% |
Relationships between endpoints
↥Index endpoint: AD_EO_EXMORE – Alzheimer’s disease (Early onset)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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