rubella: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis. [ url:http://en.wikipedia.org/wiki/Rubella ]
Viral infections characterized by skin and mucous membrane lesions
DOID EFO Endpoint Browser PheWeb
AB1_VIRAL_SKIN_MUCOUS_MEMBRANE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
14664 |
4. Check minimum number of eventsNone |
14664 |
5. Include endpoints |
18547 |
6. Filter based on genotype QC (FinnGen only) |
17861 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 191273 | 94937 | 95357 |
Only index persons | 160628 | 80030 | 80598 |
Unadjusted period prevalence (%) | |||
Whole population | 2.68 | 2.72 | 2.66 |
Only index persons | 3.01 | 2.94 | 3.08 |
Median age at first event (years) | |||
Whole population | 31.40 | 41.93 | 20.66 |
Only index persons | 31.83 | 42.87 | 20.87 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 17861 | 9874 | 7987 |
Unadjusted period prevalence (%) | 3.94 | 3.88 | 4.01 |
Median age at first event (years) | 45.27 | 47.74 | 42.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_VIRAL_SKIN_MUCOUS_MEMBRANE and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
AB1_VIRAL_SKIN_MUCOUS_MEMBRANE | 1.432 [1.3, 1.58] | < 0.001 |
Birth year | 0.997 [0.99, 1.0] | 0.38 |
During the follow-up period (1.1.1998 — 31.12.2019), 10694 out of 65621 females with AB1_VIRAL_SKIN_MUCOUS_MEMBRANE died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
AB1_VIRAL_SKIN_MUCOUS_MEMBRANE | 1.589 [1.43, 1.77] | < 0.001 |
Birth year | 0.991 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 7995 out of 50638 males with AB1_VIRAL_SKIN_MUCOUS_MEMBRANE died.
Mortality risk
Mortality risk for people of age
years, who have AB1_VIRAL_SKIN_MUCOUS_MEMBRANE.N-year risk | Females | Males |
---|---|---|
1 | 0.194% | 0.272% |
5 | 1.002% | 2.095% |
10 | 2.321% | 4.878% |
15 | 4.209% | 9.695% |
20 | 7.825% | 16.001% |
Relationships between endpoints
↥Index endpoint: AB1_VIRAL_SKIN_MUCOUS_MEMBRANE – Viral infections characterized by skin and mucous membrane lesions
GWS hits: 1