Viral infections characterized by skin and mucous membrane lesions

AB1_VIRAL_SKIN_MUCOUS_MEMBRANE

rubella: A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis. [ url:http://en.wikipedia.org/wiki/Rubella ]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B00-B09
  • Hospital discharge: ICD-9 078[0-4]
  • Hospital discharge: ICD-8 079[0-1]
  • Hospital discharge: excluded ICD-9 0781C|0785|078[7-8]
  • Cause of death: ICD-10 B00-B09
  • Cause of death: ICD-9 078[0-4]
  • Cause of death: ICD-8 079[0-1]
  • Cause of death: excluded ICD-9 0781C|0785|078[7-8]

2 out of 7 registries used, show all original rules.

14664

4. Check minimum number of events

None

14664

5. Include endpoints

18547

6. Filter based on genotype QC (FinnGen only)

17861

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 191273 94937 95357
Only index persons 160628 80030 80598
Unadjusted period prevalence (%)
Whole population 2.68 2.72 2.66
Only index persons 3.01 2.94 3.08
Median age at first event (years)
Whole population 31.40 41.93 20.66
Only index persons 31.83 42.87 20.87

-FinnGen-

Key figures

All Female Male
Number of individuals 17861 9874 7987
Unadjusted period prevalence (%) 3.94 3.88 4.01
Median age at first event (years) 45.27 47.74 42.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_VIRAL_SKIN_MUCOUS_MEMBRANE and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_SKIN_MUCOUS_MEMBRANE 1.432 [1.3, 1.58] < 0.001
Birth year 0.997 [0.99, 1.0] 0.38

During the follow-up period (1.1.1998 — 31.12.2019), 10694 out of 65621 females with AB1_VIRAL_SKIN_MUCOUS_MEMBRANE died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_SKIN_MUCOUS_MEMBRANE 1.589 [1.43, 1.77] < 0.001
Birth year 0.991 [0.98, 1.0] 0.053

During the follow-up period (1.1.1998 — 31.12.2019), 7995 out of 50638 males with AB1_VIRAL_SKIN_MUCOUS_MEMBRANE died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_SKIN_MUCOUS_MEMBRANE.

N-year risk Females Males
1 0.194% 0.272%
5 1.002% 2.095%
10 2.321% 4.878%
15 4.209% 9.695%
20 7.825% 16.001%

Relationships between endpoints

Index endpoint: AB1_VIRAL_SKIN_MUCOUS_MEMBRANE – Viral infections characterized by skin and mucous membrane lesions

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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