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Zoster [herpes zoster]

EFO Endpoint Browser PheWeb

AB1_ZOSTER

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B02
  • Hospital discharge: ICD-9 — 05[3]
  • Hospital discharge: ICD-8 — 05[3]
  • Cause of death: ICD-10 — B02
  • Cause of death: ICD-9 — 05[3]
  • Cause of death: ICD-8 — 05[3]

2 out of 7 registries used, show all original rules.

6523

4. Check minimum number of events

None

6523

5. Include endpoints

None

6523

6. Filter based on genotype QC (FinnGen only)

6268

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 58464 34906 23029
Only index persons 47995 29009 18986
Unadjusted period prevalence (%)
Whole population 0.86 1.00 0.64
Only index persons 0.93 1.07 0.72
Median age at first event (years)
Whole population 68.79 70.21 66.69
Only index persons 67.63 69.09 65.40

-FinnGen-

Key figures

All Female Male
Number of individuals 6268 3692 2576
Unadjusted period prevalence (%) 1.39 1.45 1.29
Median age at first event (years) 65.79 64.16 68.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_ZOSTER and mortality.

Females

Parameter HR [95% CI] p-value
AB1_ZOSTER 1.44 [1.31, 1.58] < 0.001
Birth year 0.992 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 7716 out of 24100 females with AB1_ZOSTER died.

Males

Parameter HR [95% CI] p-value
AB1_ZOSTER 1.591 [1.42, 1.78] < 0.001
Birth year 0.989 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 4984 out of 15694 males with AB1_ZOSTER died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ZOSTER.

N-year risk Females Males
1 0.103% 0.298%
5 0.668% 1.907%
10 1.762% 4.73%
15 3.41% 8.624%
20 6.301% 14.794%

Relationships between endpoints

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Index endpoint: AB1_ZOSTER – Zoster [herpes zoster]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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