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Herpesviral [herpes simplex] infections

EFO Endpoint Browser PheWeb

AB1_HERPES_SIMPLEX

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B00
  • Hospital discharge: ICD-9 — 05[4]
  • Hospital discharge: ICD-8 — 05[4]
  • Hospital discharge: excluded ICD-9 — 0541A
  • Hospital discharge: excluded ICD-8 — 0540[2]
  • Cause of death: ICD-10 — B00
  • Cause of death: ICD-9 — 05[4]
  • Cause of death: ICD-8 — 05[4]
  • Cause of death: excluded ICD-9 — 0541A
  • Cause of death: excluded ICD-8 — 0540[2]

2 out of 7 registries used, show all original rules.

4343

4. Check minimum number of events

None

4343

5. Include endpoints

None

4343

6. Filter based on genotype QC (FinnGen only)

4159

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37387 21787 15388
Only index persons 33592 20093 13499
Unadjusted period prevalence (%)
Whole population 0.54 0.62 0.43
Only index persons 0.65 0.74 0.52
Median age at first event (years)
Whole population 41.45 42.64 39.62
Only index persons 40.80 42.22 38.70

-FinnGen-

Key figures

All Female Male
Number of individuals 4159 2766 1393
Unadjusted period prevalence (%) 0.96 1.09 0.70
Median age at first event (years) 48.16 45.58 53.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_HERPES_SIMPLEX and mortality.

Females

Parameter HR [95% CI] p-value
AB1_HERPES_SIMPLEX 1.414 [1.26, 1.59] < 0.001
Birth year 0.994 [0.99, 1.0] 0.132

During the follow-up period (1.1.1998 — 31.12.2019), 2089 out of 15898 females with AB1_HERPES_SIMPLEX died.

Males

Parameter HR [95% CI] p-value
AB1_HERPES_SIMPLEX 1.583 [1.4, 1.78] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 1872 out of 10705 males with AB1_HERPES_SIMPLEX died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HERPES_SIMPLEX.

N-year risk Females Males
1 0.134% 0.29%
5 0.861% 1.828%
10 2.098% 4.349%
15 3.939% 8.385%
20 6.991% 13.889%

Relationships between endpoints

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Index endpoint: AB1_HERPES_SIMPLEX – Herpesviral [herpes simplex] infections

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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