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Varicella [chickenpox]

EFO Endpoint Browser PheWeb

AB1_VARICELLA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B01
  • Hospital discharge: ICD-9 — 05[2]
  • Hospital discharge: ICD-8 — 05[2]
  • Cause of death: ICD-10 — B01
  • Cause of death: ICD-9 — 05[2]
  • Cause of death: ICD-8 — 05[2]

2 out of 7 registries used, show all original rules.

1714

4. Check minimum number of events

None

1714

5. Include endpoints

None

1714

6. Filter based on genotype QC (FinnGen only)

1644

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24317 7662 16552
Only index persons 20463 6106 14357
Unadjusted period prevalence (%)
Whole population 0.38 0.22 0.46
Only index persons 0.45 0.22 0.55
Median age at first event (years)
Whole population 15.07 5.26 19.52
Only index persons 15.83 6.61 19.75

-FinnGen-

Key figures

All Female Male
Number of individuals 1644 529 1115
Unadjusted period prevalence (%) 0.45 0.21 0.56
Median age at first event (years) 17.20 10.89 20.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_VARICELLA and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VARICELLA 2.371 [1.77, 3.17] < 0.001
Birth year 0.998 [0.99, 1.01] 0.578

During the follow-up period (1.1.1998 — 31.12.2019), 230 out of 5335 females with AB1_VARICELLA died.

Males

Parameter HR [95% CI] p-value
AB1_VARICELLA 2.514 [1.95, 3.24] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 291 out of 6337 males with AB1_VARICELLA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VARICELLA.

N-year risk Females Males
1 0.272% 0.409%
5 1.555% 2.968%
10 3.899% 7.396%
15 7.226% 14.074%
20 12.554% 22.812%

Relationships between endpoints

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Index endpoint: AB1_VARICELLA – Varicella [chickenpox]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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