Other viral infections characterized by skin and mucous membrane lesions, not elsewhere classified

AB1_VIRAL_SKIN_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B08, B09
  • Hospital discharge: ICD-9 057
  • Hospital discharge: ICD-8 057
  • Cause of death: ICD-10 B08, B09
  • Cause of death: ICD-9 057
  • Cause of death: ICD-8 057

2 out of 7 registries used, show all original rules.

1337

4. Check minimum number of events

None

1337

5. Include endpoints

None

1337

6. Filter based on genotype QC (FinnGen only)

1287

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 28589 13897 14649
Only index persons 18938 9296 9642
Unadjusted period prevalence (%)
Whole population 0.40 0.40 0.41
Only index persons 0.36 0.34 0.37
Median age at first event (years)
Whole population 2.18 2.31 1.97
Only index persons 2.76 3.27 2.27

-FinnGen-

Key figures

All Female Male
Number of individuals 1287 803 484
Unadjusted period prevalence (%) 0.29 0.32 0.24
Median age at first event (years) 8.69 8.78 8.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_VIRAL_SKIN_NOS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_SKIN_NOS 1.294 [0.99, 1.68] 0.055
Birth year 0.991 [0.98, 1.0] 0.042

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 9236 females with AB1_VIRAL_SKIN_NOS died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_SKIN_NOS 1.53 [1.19, 1.97] 0.001
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 9318 males with AB1_VIRAL_SKIN_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_SKIN_NOS.

N-year risk Females Males
1 0.102% 0.274%
5 0.692% 1.95%
10 1.648% 4.642%
15 3.33% 8.646%
20 5.563% 14.317%

Relationships between endpoints

Index endpoint: AB1_VIRAL_SKIN_NOS – Other viral infections characterized by skin and mucous membrane lesions, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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