obsolete_tuberculosis: ['A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004', 'Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2864 |
4. Check minimum number of eventsNone |
2864 |
5. Include endpoints |
2949 |
6. Filter based on genotype QC (FinnGen only) |
2811 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Tuberculosis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 48519 | 21137 | 25875 |
| Only index persons | 25041 | 12800 | 12241 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.70 | 0.61 | 0.72 |
| Only index persons | 0.47 | 0.47 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 53.53 | 53.62 | 53.34 |
| Only index persons | 44.14 | 44.42 | 43.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2811 | 1079 | 1732 |
| Unadjusted period prevalence (%) | 0.70 | 0.42 | 0.87 |
| Median age at first event (years) | 46.72 | 39.64 | 51.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_TUBERCULOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TUBERCULOSIS | 1.898 [1.73, 2.09] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.167 |
During the follow-up period (1.1.1998 — 31.12.2019), 2139 out of 4624 females with AB1_TUBERCULOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TUBERCULOSIS | 2.451 [2.19, 2.74] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 3252 out of 5855 males with AB1_TUBERCULOSIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_TUBERCULOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.197% | 0.417% |
| 5 | 1.084% | 2.623% |
| 10 | 2.86% | 6.862% |
| 15 | 5.108% | 12.978% |
| 20 | 8.989% | 20.557% |
Relationships between endpoints
↥Index endpoint: AB1_TUBERCULOSIS – Tuberculosis
GWS hits: 1
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