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Tuberculosis of other organs

EFO Endpoint Browser PheWeb

AB1_TUBERCU_OTH_ORG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A18
  • Hospital discharge: ICD-9 — 0[1]
  • Hospital discharge: ICD-8 — 0[1]
  • Hospital discharge: excluded ICD-9 — 01[1-3]|018
  • Hospital discharge: excluded ICD-8 — 01[1-3]|018
  • Cause of death: ICD-10 — A18
  • Cause of death: ICD-9 — 0[1]
  • Cause of death: ICD-8 — 0[1]
  • Cause of death: excluded ICD-9 — 01[1-3]|018
  • Cause of death: excluded ICD-8 — 01[1-3]|018

2 out of 7 registries used, show all original rules.

843

4. Check minimum number of events

None

843

5. Include endpoints

None

843

6. Filter based on genotype QC (FinnGen only)

800

Control definitions (FinnGen only)

Control exclude AB1_TUBERCULOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14840 7877 6491
Only index persons 8037 4922 3115
Unadjusted period prevalence (%)
Whole population 0.21 0.23 0.18
Only index persons 0.16 0.18 0.12
Median age at first event (years)
Whole population 54.25 54.45 54.01
Only index persons 46.80 48.59 43.96

-FinnGen-

Key figures

All Female Male
Number of individuals 800 394 406
Unadjusted period prevalence (%) 0.18 0.15 0.20
Median age at first event (years) 48.44 44.88 51.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_TUBERCU_OTH_ORG and mortality.

Females

Parameter HR [95% CI] p-value
AB1_TUBERCU_OTH_ORG 1.523 [1.36, 1.71] < 0.001
Birth year 0.997 [0.99, 1.01] 0.42

During the follow-up period (1.1.1998 — 31.12.2019), 693 out of 1730 females with AB1_TUBERCU_OTH_ORG died.

Males

Parameter HR [95% CI] p-value
AB1_TUBERCU_OTH_ORG 1.85 [1.57, 2.18] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1311 males with AB1_TUBERCU_OTH_ORG died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TUBERCU_OTH_ORG.

N-year risk Females Males
1 0.092% 0.383%
5 0.859% 2.039%
10 2.049% 5.092%
15 4.14% 9.389%
20 7.541% 15.862%

Relationships between endpoints

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Index endpoint: AB1_TUBERCU_OTH_ORG – Tuberculosis of other organs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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