pulmonary tuberculosis: A bacterial infection that affects the lungs and is caused by Mycobacterium tuberculosis. Most patients with tuberculosis do not have symptoms (latent tuberculosis) and are not contagious. When signs and symptoms occur (active tuberculosis), patients become contagious. The signs and symptoms include chronic cough with blood-tinged sputum, night sweats, fever, fatigue, and weight loss.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
2155 |
6. Filter based on genotype QC (FinnGen only) |
2061 |
Control definitions (FinnGen only)
Control exclude
IBD_TUBERCULOSIS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Respiratory tuberculosis
based on the number of shared cases.
Similar with more cases:
- Respiratory tuberculosis
- Tuberculosis
- Tuberculosis, IBD comorbidity
- Tuberculosis
- Infections, IBD-co-morbidities
Similar with less cases:
- Respiratory tuberculosis
- Respiratory tuberculosis, not confirmed bacteriologically or histologically
- Respiratory TBC, ICD-8 codes not specifying whether confirmed bacteriologically or histologically
- Respiratory tuberculosis, bacteriologically and histologically confirmed
- Respiratory tuberculosis, bacteriologically and histologically confirmed
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 34910 | 13713 | 20113 |
| Only index persons | 17505 | 8163 | 9342 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.51 | 0.39 | 0.56 |
| Only index persons | 0.33 | 0.30 | 0.36 |
| Median age at first event (years) | |||
| Whole population | 53.02 | 52.55 | 53.15 |
| Only index persons | 42.73 | 41.60 | 43.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2061 | 700 | 1361 |
| Unadjusted period prevalence (%) | 0.54 | 0.27 | 0.68 |
| Median age at first event (years) | 46.04 | 37.17 | 50.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint TBC_RESP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| TBC_RESP | 2.077 [1.85, 2.33] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.314 |
During the follow-up period (1.1.1998 — 31.12.2019), 1483 out of 2958 females with TBC_RESP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| TBC_RESP | 2.815 [2.49, 3.19] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2702 out of 4601 males with TBC_RESP died.
Mortality risk
Mortality risk for people of age
years, who have TBC_RESP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.237% | 0.513% |
| 5 | 1.239% | 3.228% |
| 10 | 3.108% | 7.591% |
| 15 | 5.846% | 14.501% |
| 20 | 10.563% | 23.591% |
Relationships between endpoints
↥Index endpoint: TBC_RESP – Respiratory tuberculosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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