≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Respiratory tuberculosis, not confirmed bacteriologically or histologically

EFO Endpoint Browser PheWeb

AB1_RESP_TUBERCU_NONCONF

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A16
  • Hospital discharge: ICD-9 — 01[1-2]
  • Hospital discharge: ICD-8 — 01[1-2]
  • Hospital discharge: excluded ICD-9 — 01[1-2].A
  • Cause of death: ICD-10 — A16
  • Cause of death: ICD-9 — 01[1-2]
  • Cause of death: ICD-8 — 01[1-2]
  • Cause of death: excluded ICD-9 — 01[1-2].A

2 out of 7 registries used, show all original rules.

1569

4. Check minimum number of events

None

1569

5. Include endpoints

None

1569

6. Filter based on genotype QC (FinnGen only)

1513

Control definitions (FinnGen only)

Control exclude AB1_TUBERCULOSIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26949 10715 15412
Only index persons 12955 6283 6672
Unadjusted period prevalence (%)
Whole population 0.39 0.31 0.43
Only index persons 0.24 0.23 0.25
Median age at first event (years)
Whole population 49.87 48.85 50.29
Only index persons 38.41 38.00 38.81

-FinnGen-

Key figures

All Female Male
Number of individuals 1513 522 991
Unadjusted period prevalence (%) 0.40 0.21 0.50
Median age at first event (years) 40.96 32.44 45.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_RESP_TUBERCU_NONCONF and mortality.

Females

Parameter HR [95% CI] p-value
AB1_RESP_TUBERCU_NONCONF 2.647 [2.24, 3.13] < 0.001
Birth year 0.993 [0.98, 1.0] 0.118

During the follow-up period (1.1.1998 — 31.12.2019), 641 out of 1245 females with AB1_RESP_TUBERCU_NONCONF died.

Males

Parameter HR [95% CI] p-value
AB1_RESP_TUBERCU_NONCONF 2.682 [2.28, 3.16] < 0.001
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 1179 out of 1955 males with AB1_RESP_TUBERCU_NONCONF died.

Mortality risk

Mortality risk for people of age

years, who have AB1_RESP_TUBERCU_NONCONF.

N-year risk Females Males
1 0.247% 0.493%
5 1.684% 3.329%
10 3.933% 8.096%
15 6.764% 15.062%
20 12.124% 24.76%

Relationships between endpoints

↥

Index endpoint: AB1_RESP_TUBERCU_NONCONF – Respiratory tuberculosis, not confirmed bacteriologically or histologically

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data