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Respiratory tuberculosis, bacteriologically and histologically confirmed

EFO Endpoint Browser PheWeb

AB1_RESP_TUBERCU_CONF

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A15
  • Hospital discharge: ICD-9 — 01[1-2].A
  • Cause of death: ICD-10 — A15
  • Cause of death: ICD-9 — 01[1-2].A

2 out of 7 registries used, show all original rules.

681

4. Check minimum number of events

None

681

5. Include endpoints

None

681

6. Filter based on genotype QC (FinnGen only)

638

Control definitions (FinnGen only)

Control exclude AB1_TUBERCULOSIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10043 3678 6041
Only index persons 5568 2240 3328
Unadjusted period prevalence (%)
Whole population 0.15 0.11 0.17
Only index persons 0.11 0.08 0.13
Median age at first event (years)
Whole population 65.07 68.60 63.07
Only index persons 58.70 59.64 58.07

-FinnGen-

Key figures

All Female Male
Number of individuals 638 201 437
Unadjusted period prevalence (%) 0.18 0.08 0.22
Median age at first event (years) 63.18 56.18 66.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_RESP_TUBERCU_CONF and mortality.

Females

Parameter HR [95% CI] p-value
AB1_RESP_TUBERCU_CONF 2.229 [1.96, 2.54] < 0.001
Birth year 0.992 [0.98, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 994 out of 2033 females with AB1_RESP_TUBERCU_CONF died.

Males

Parameter HR [95% CI] p-value
AB1_RESP_TUBERCU_CONF 2.551 [2.23, 2.92] < 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 1865 out of 3273 males with AB1_RESP_TUBERCU_CONF died.

Mortality risk

Mortality risk for people of age

years, who have AB1_RESP_TUBERCU_CONF.

N-year risk Females Males
1 0.13% 0.496%
5 0.995% 2.92%
10 2.597% 6.619%
15 5.126% 11.95%
20 9.257% 20.013%

Relationships between endpoints

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Index endpoint: AB1_RESP_TUBERCU_CONF – Respiratory tuberculosis, bacteriologically and histologically confirmed

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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