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Tuberculosis of nervous system

AB1_TUBERCU_NEU

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A17
  • Hospital discharge: ICD-9 01[3]
  • Hospital discharge: ICD-8 01[3]
  • Cause of death: ICD-10 A17
  • Cause of death: ICD-9 01[3]
  • Cause of death: ICD-8 01[3]

2 out of 7 registries used, show all original rules.

45

4. Check minimum number of events

None

45

5. Include endpoints

None

45

6. Filter based on genotype QC (FinnGen only)

41

Control definitions (FinnGen only)

Control exclude AB1_TUBERCULOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 600 293 286
Only index persons 340 181 159
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 58.42 59.18 58.14
Only index persons 50.32 47.69 53.31

-FinnGen-

Key figures

All Female Male
Number of individuals 41 21 20
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 52.53 42.48 63.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint AB1_TUBERCU_NEU and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_TUBERCU_NEU 3.102 [1.98, 4.86] < 0.001
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 121 males with AB1_TUBERCU_NEU died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TUBERCU_NEU.

N-year risk Females Males
1 No data 0.547%
5 No data 3.433%
10 No data 8.635%
15 No data 15.568%
20 No data 24.871%

Relationships between endpoints

Index endpoint: AB1_TUBERCU_NEU – Tuberculosis of nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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