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Miliary tuberculosis

EFO Endpoint Browser

AB1TUBERCU_MILIARY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A19
  • Hospital discharge: ICD-9 — 01[8]
  • Hospital discharge: ICD-8 — 01[8]
  • Cause of death: ICD-10 — A19
  • Cause of death: ICD-9 — 01[8]
  • Cause of death: ICD-8 — 01[8]

2 out of 7 registries used, show all original rules.

51

4. Check minimum number of events

None

51

5. Include endpoints

None

51

6. Filter based on genotype QC (FinnGen only)

49

Control definitions (FinnGen only)

Control exclude AB1_TUBERCULOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1151 536 575
Only index persons 525 252 273
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 69.91 73.54 66.67
Only index persons 65.62 67.62 63.77

-FinnGen-

Key figures

All Female Male
Number of individuals 49 17 32
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 69.99 66.80 71.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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Association

Association between endpoint AB1TUBERCU_MILIARY and mortality.

Females

Parameter HR [95% CI] p-value
AB1TUBERCU_MILIARY 2.344 [1.68, 3.27] < 0.001
Birth year 0.994 [0.99, 1.0] 0.142

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 196 females with AB1TUBERCU_MILIARY died.

Males

Parameter HR [95% CI] p-value
AB1TUBERCU_MILIARY 3.085 [2.04, 4.67] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 241 males with AB1TUBERCU_MILIARY died.

Mortality risk

Mortality risk for people of age

years, who have AB1TUBERCU_MILIARY.

N-year risk Females Males
1 0.247% 0.503%
5 1.401% 3.278%
10 3.368% 8.075%
15 6.323% 14.981%
20 11.127% 24.438%

Relationships between endpoints

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Index endpoint: AB1TUBERCU_MILIARY – Miliary tuberculosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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