No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
G6_PARKINSON, F5_PSYCH, NEURODIS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Dementia due to Parkinsons disease
based on the number of shared cases.
Similar with more cases:
- Dementia due to Parkinson's disease
- Dementia in other diseases classified elsewhere
- Any dementia
- Any dementia
- Dementia
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9967 | 4278 | 5570 |
| Only index persons | 8196 | 3544 | 4652 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.12 | 0.16 |
| Only index persons | 0.16 | 0.13 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 77.63 | 78.85 | 76.70 |
| Only index persons | 77.59 | 78.87 | 76.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 643 | 217 | 426 |
| Unadjusted period prevalence (%) | 0.17 | 0.09 | 0.21 |
| Median age at first event (years) | 76.77 | 77.65 | 76.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PD_DEMENTIA_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PD_DEMENTIA_EXMORE | 4.002 [3.47, 4.62] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.35 |
During the follow-up period (1.1.1998 — 31.12.2019), 2678 out of 3661 females with PD_DEMENTIA_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PD_DEMENTIA_EXMORE | 4.506 [3.75, 5.41] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 3543 out of 4687 males with PD_DEMENTIA_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have PD_DEMENTIA_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.287% | 1.034% |
| 5 | 2.261% | 5.714% |
| 10 | 5.45% | 13.843% |
| 15 | 10.744% | 24.757% |
| 20 | 18.651% | 38.964% |
Relationships between endpoints
↥Index endpoint: PD_DEMENTIA_EXMORE – Dementia due to Parkinsons disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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