Dementia due to Parkinsons disease

PD_DEMENTIA_EXMORE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude G6_PARKINSON, F5_PSYCH, NEURODIS

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9967 4278 5570
Only index persons 8196 3544 4652
Unadjusted period prevalence (%)
Whole population 0.14 0.12 0.16
Only index persons 0.16 0.13 0.18
Median age at first event (years)
Whole population 77.63 78.85 76.70
Only index persons 77.59 78.87 76.63

-FinnGen-

Key figures

All Female Male
Number of individuals 643 217 426
Unadjusted period prevalence (%) 0.17 0.09 0.21
Median age at first event (years) 76.77 77.65 76.31

-FinRegistry-

Age distribution of first events

02050607080900.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0k4.5kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304060708090050100150200250300AgeIndividuals

-FinRegistry-

Year distribution of first events

197019751980198519952000200520102015202020220.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8k2.0k2.2k2.4k2.6k2.8kYearIndividuals

-FinnGen-

Year distribution of first events

19701975198019851990199520052010201520202023020406080100120140160180200YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

Mortality – FinRegistry

Association

Association between endpoint PD_DEMENTIA_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
PD_DEMENTIA_EXMORE 4.002 [3.47, 4.62] < 0.001
Birth year 0.996 [0.99, 1.0] 0.35

During the follow-up period (1.1.1998 — 31.12.2019), 2678 out of 3661 females with PD_DEMENTIA_EXMORE died.

Males

Parameter HR [95% CI] p-value
PD_DEMENTIA_EXMORE 4.506 [3.75, 5.41] < 0.001
Birth year 0.99 [0.98, 1.0] 0.032

During the follow-up period (1.1.1998 — 31.12.2019), 3543 out of 4687 males with PD_DEMENTIA_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have PD_DEMENTIA_EXMORE.

N-year risk Females Males
1 0.287% 1.034%
5 2.261% 5.714%
10 5.45% 13.843%
15 10.744% 24.757%
20 18.651% 38.964%

Relationships between endpoints

Index endpoint: PD_DEMENTIA_EXMORE – Dementia due to Parkinsons disease

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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